KRH-3955 (hydrochloride)

KRH-3955 hydrochloride is an orally bioavailable CXCR4 antagonist. KRH-3955 hydrochloride inhibits SDF-1α binding to CXCR4 with an IC50 of 0.61 nM. KRH-3955 hydrochloride is also a highly potent and selective inhibitor of X4 HIV-1, with an EC50 of 0.3 to 1.0 nM[1].

Product Specifications

CAS Number

[2253744-59-9]

UNSPSC

12352005

Target

CXCR; HIV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/krh-3955-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CCCN(CCC)CCCCN(CC1=CC=C(CN(CC2=NC=CN2)CC3=NC=CN3C)C=C1)C.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C28H48Cl3N7

Molecular Weight

589.09

References & Citations

[1]Tsutomu M, et, al. The Novel CXCR4 Antagonist KRH-3955 Is an Orally Bioavailable and Extremely Potent Inhibitor of Human Immunodeficiency Virus Type 1 Infection: Comparative Studies With AMD3100. Antimicrob Agents Chemother. 2009 Jul; 53 (7) : 2940-8.