UK‑396082
UK‑396082 is a potent thrombin activated fibrinolytic inhibitor (TAFI) inhibitor. UK‑396082 increases plasmin activity and induces a parallel decrease in ECM levels. UK‑396082 can be used in research of chronic kidney disease (CKD) [1].
Product Specifications
CAS Number
[400044-47-5]
UNSPSC
12352005
Target
Thrombin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/uk-396082.html
Purity
99.89
Solubility
10 mM in DMSO
Smiles
CCCN1C=C(C[C@@H](C(O)=O)CCCN)N=C1
Molecular Formula
C12H21N3O2
Molecular Weight
239.31
References & Citations
[1]Atkinson JM, et, al. An inhibitor of thrombin activated fibrinolysis inhibitor (TAFI) can reduce extracellular matrix accumulation in an in vitro model of glucose induced ECM expansion. Matrix Biol. 2013 Jun 24;32 (5) :277-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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