DSHN
DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer[1].
Product Specifications
CAS Number
313952-63-5
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dshn.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=C(C=C2C(S(=O)(N(CC)CC)=O)=CC=CC2=C1)O
Molecular Formula
C15H17NO5S
Molecular Weight
323.36
References & Citations
[1]Yang Z, et, al. A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2. Mol Cancer Ther. 2016 Oct;15 (10) :2294-2301.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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