(Z) -KC02
(Z) -KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC) . (Z) -KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z) -KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1].
Product Specifications
CAS Number
1646795-60-9
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z-kc02.html
Concentration
34.80 mM * 100 μL in Ethyl acetate
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(N)CCCC/C=C1C(OC\1CCC2=CC=CC=C2)=O
Molecular Formula
C17H21NO3
Molecular Weight
287.35
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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