3-Deazaneplanocin A (hydrochloride) (GMP)

3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor[1][2].

Product Specifications

CAS Number

[120964-45-6]

Product Name Alternative

DZNep (hydrochloride) (GMP) ; NSC 617989 (hydrochloride) (GMP) ; 3-Deazaneplanocin (hydrochloride) (GMP)

UNSPSC

12352005

Hazard Statement

H302

Target

Histone Methyltransferase; Orthopoxvirus

Type

GMP Small Molecules

Related Pathways

Anti-infection; Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/3-deazaneplanocin-a-hydrochloride-gmp.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl

Molecular Formula

C12H15ClN4O3

Molecular Weight

298.73

Precautions

P264-P270-P330-P501

References & Citations

[1]Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood. 2009 Sep 24;114 (13) :2733-43. |[2]Hou P, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341 (6146) :651-4. |[3]Zhao C, et al. DZNep and UNC0642 enhance in vitro developmental competence of cloned pig embryos. Reproduction. 2018 Apr 1;157 (4) :359-369.