RU28362
Product Specifications
UNSPSC Description
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ru28362.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@@](O)(CC[C@]4([C@@]3(C=C(C2=C1)C)[H])[H])C#CC)C)O)[H])C
Molecular Weight
352.47
References & Citations
[1]Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94.|[2]Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121859/RU28362-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121859/
Clinical Information
No Development Reported
CAS Number
74915-64-3
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