U-44069
U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels[1].
Product Specifications
CAS Number
56985-32-1
UNSPSC
12352005
Hazard Statement
H225, H319, H336
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/u-44069.html
Concentration
28.53 mM * 100 μL in Methyl acetate
Purity
98.0
Solubility
10 mM in DMSO
Smiles
OC(CCC/C=C\C[C@@H]1[C@H]([C@@]2([H])C[C@]1([H])OC2)/C=C/[C@@H](O)CCCCC)=O
Molecular Formula
C21H34O4
Molecular Weight
350.49
Precautions
H225, H319, H336
References & Citations
[1]Simpson AW, et, al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Lett. 1986 Jun 9;201 (2) :301-5.|[2]Loutzenhiser R, et, al. Reversal of renal and smooth muscle actions of the thromboxane mimetic U-44069 by diltiazem. Am J Physiol. 1986 Apr;250 (4 Pt 2) :F619-26.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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