U-44069

U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels[1].

Product Specifications

CAS Number

[56985-32-1]

UNSPSC

12352005

Hazard Statement

H225, H319, H336

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/u-44069.html

Concentration

28.53 mM * 100 μL in Methyl acetate

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C[C@@H]1[C@H]([C@@]2([H])C[C@]1([H])OC2)/C=C/[C@@H](O)CCCCC)=O

Molecular Formula

C21H34O4

Molecular Weight

350.49

Precautions

H225, H319, H336

References & Citations

[1]Simpson AW, et, al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Lett. 1986 Jun 9;201 (2) :301-5.|[2]Loutzenhiser R, et, al. Reversal of renal and smooth muscle actions of the thromboxane mimetic U-44069 by diltiazem. Am J Physiol. 1986 Apr;250 (4 Pt 2) :F619-26.