PF-00217830

F-00217830 is an agonist ofDopamine D2 receptor. PF-00217830 inhibits of spontaneous locomotor activity and 2,5-dimethoxy-4-iodoamphetamine-induced head twitches in rats[1].

Product Specifications

CAS Number

[846032-02-8]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-00217830.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C2NC(OCCCCN3CCN(CC3)C4=C5C=CC=CC5=CC=C4)=CC=C2CC1

Molecular Formula

C26H30N4O2

Molecular Weight

430.54

References & Citations

[1]Johnson DS, et al. Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder. Bioorg Med Chem Lett. 2011;21 (9) :2621-2625.