MPCI
MPCI is a cell-permeant MC4R-selective ligand with pharmacological chaperone activity. MPCI is a MC4R antagonist with a Ki value of 0.218 μM on HEK293 cells expressing hMC4R. MPCI can be used for the research of MC4R-deficient obesity[1].
Product Specifications
CAS Number
884538-31-2
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mpci.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(F)=C1CCC2=CC(Br)=CC=C2OC)NC(NCC3CCN(CC3)CC)=N
Molecular Formula
C25H32BrFN4O2
Molecular Weight
519.45
References & Citations
[1]René P, et al. Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity. J Pharmacol Exp Ther. 2010 Dec;335 (3) :520-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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