NTE-122 (dihydrochloride)
Product Specifications
UNSPSC Description
NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].
Target Antigen
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nte-122-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
CN(C)C(C=C1)=CC=C1NC(N(C2CCCCC2)C[C@@H](CC3)CC[C@H]3CN(C4CCCCC4)C(NC5=CC=C(C=C5)N(C)C)=O)=O.Cl.Cl
Molecular Weight
703.83
References & Citations
[1]Y Azuma, et al. NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121762/NTE-122-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121762/
Clinical Information
No Development Reported
CAS Number
166967-84-6
Curated Selection
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