NTE-122 (dihydrochloride)

NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with the IC50 in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis[1].

Product Specifications

CAS Number

[166967-84-6]

UNSPSC

12352005

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nte-122-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

CN(C)C(C=C1)=CC=C1NC(N(C2CCCCC2)C[C@@H](CC3)CC[C@H]3CN(C4CCCCC4)C(NC5=CC=C(C=C5)N(C)C)=O)=O.Cl.Cl

Molecular Formula

C38H60Cl2N6O2

Molecular Weight

703.83

References & Citations

[1]Y Azuma, et al. NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits. Jpn J Pharmacol. 2001 May;86 (1) :120-3.