TC AC 28

TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2 (2), Brd2 (1), respectively[1].

Product Specifications

CAS Number

1809296-92-1

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tc-ac-28.html

Solubility

10 mM in DMSO

Smiles

COC(CC1N=C(C2=C3C=CNC3=CC=C2)C4=CC(OC)=CC=C4N5C(C)=NN=C15)=O

Molecular Formula

C23H21N5O3

Molecular Weight

415.44

References & Citations

[1]Khan R, et al. Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand. ACS Omega. 2017 Aug 8;2 (8) :4328-4332.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD2

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