TC AC 28
TC AC 28 is a high-affinity BET bromodomain ligand with Kd values of 40, 800 nM for Brd2 (2), Brd2 (1), respectively[1].
Product Specifications
CAS Number
1809296-92-1
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tc-ac-28.html
Solubility
10 mM in DMSO
Smiles
COC(CC1N=C(C2=C3C=CNC3=CC=C2)C4=CC(OC)=CC=C4N5C(C)=NN=C15)=O
Molecular Formula
C23H21N5O3
Molecular Weight
415.44
References & Citations
[1]Khan R, et al. Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand. ACS Omega. 2017 Aug 8;2 (8) :4328-4332.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2
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