Tipepidine
Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA (GIRK) ) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
Product Specifications
CAS Number
5169-78-8
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tipepidine.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3
Molecular Formula
C15H17NS2
Molecular Weight
275.43
References & Citations
[1]Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34.|[2]Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
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