Tanomastat
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].
Product Specifications
CAS Number
179545-77-8
Product Name Alternative
BAY 12-9566
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tanomastat.html
Purity
99.7
Solubility
DMSO : 25 mg/mL (ultrasonic; warming)
Smiles
ClC1=CC=C(C2=CC=C(C(C[C@H](CSC3=CC=CC=C3)C(O)=O)=O)C=C2)C=C1
Molecular Formula
C23H19ClO3S
Molecular Weight
410.91
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MMP-13; MMP-2; MMP-3; MMP-9
Frequently Asked Questions
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