AQ4
AQ4 is a topoisomerase II inhibitor and DNA intercalator as a chemically stable cytotoxic agent in many human tumor lines[1].
Product Specifications
CAS Number
70476-63-0
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aq4.html
Purity
97.34
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(C3=C(C=CC(NCCN(C)C)=C13)NCCN(C)C)=O)C(O)=CC=C2O
Molecular Formula
C22H28N4O4
Molecular Weight
412.48
Precautions
H302, H410
References & Citations
[1]Luan X, et al. A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia. Adv Sci (Weinh) . 2018 May 28;5 (8) :1800034.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Available Sizes
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