Resolvin D2-d5

Resolvin D2-d5 is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

Product Specifications

CAS Number

[1881277-33-3]

Product Name Alternative

RvD2-d5

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Concentration

262.11 µM * 100 μL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

[2H]C(C([2H])([2H])[2H])(/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](C/C=C\CCC(O)=O)O)O)O)[2H]

Molecular Formula

C22H27D5O5

Molecular Weight

381.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307.|[3]Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461 (7268) :1287-91.|[4]Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31 (50) :18433-8.