ALLO-1

ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif[1].

Product Specifications

CAS Number

[37468-32-9]

UNSPSC

12352005

Hazard Statement

H302-H317-H319-H400

Target

Atg8/LC3; Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/allo-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C(N(C1C)CC2=CC=CC=C2)=O)C3=CC=C(C=C3)Cl

Molecular Formula

C17H15ClN2O2

Molecular Weight

314.77

Precautions

P261-P264-P270-P272-P273-P280-P302+P352-P305+P351+P338-P330-P362+P364-P391-P501

References & Citations

[1]Sato M, et al. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Nat Cell Biol. 2018 Jan;20 (1) :81-91.