Methicillin

Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs) . Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

Product Specifications

CAS Number

[61-32-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; Histamine Receptor; Penicillin-binding protein (PBP)

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/methicillin.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H]1N(C2=O)[C@@](SC(C)1C)([H])[C@@H]2NC(C(C(OC)=CC=C3)=C3OC)=O)=O

Molecular Formula

C17H20N2O6S

Molecular Weight

380.42

Precautions

P264-P270-P330-P501

References & Citations

[1]Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.|[2]Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13 (1) : 74–77.