(-) -Rasfonin
(-) -Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-) -Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) [1].
Product Specifications
CAS Number
303156-68-5
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Autophagy; Ras
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-rasfonin.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H](C=C1)[C@@H]([C@@H](C)C[C@@H](C)C/C(C)=C/C)OC1=O)/C=C/C(C)=C/[C@@H](CO)CCO
Molecular Formula
C25H38O6
Molecular Weight
434.57
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Hou B, et al. Different Role of Raptor and Rictor in Regulating Rasfonin-Induced Autophagy and Apoptosis in Renal Carcinoma Cells. Chem Biodivers. 2020;17 (12) :e2000743.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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