(-) -Rasfonin

(-) -Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-) -Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) [1].

Product Specifications

CAS Number

[303156-68-5]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Autophagy; Ras

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/minus-rasfonin.html

Solubility

10 mM in DMSO

Smiles

O=C(O[C@H](C=C1)[C@@H]([C@@H](C)C[C@@H](C)C/C(C)=C/C)OC1=O)/C=C/C(C)=C/[C@@H](CO)CCO

Molecular Formula

C25H38O6

Molecular Weight

434.57

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Hou B, et al. Different Role of Raptor and Rictor in Regulating Rasfonin-Induced Autophagy and Apoptosis in Renal Carcinoma Cells. Chem Biodivers. 2020;17 (12) :e2000743.