GSK2332255B
GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1].
Product Specifications
CAS Number
1366233-41-1
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk2332255b.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(Cl)SC(NC2=C(F)C=C(OCO3)C3=C2)=N1)N4C(C)C(C)CCC4
Molecular Formula
C18H19ClFN3O3S
Molecular Weight
411.88
References & Citations
[1]Kinya Seo, et al. Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc Natl Acad Sci U S A. 2014 Jan 28;111 (4) :1551-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPC3
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