(+) -Ochromycinone

(+) -Ochromycinone is a natural antibiotic that potently inhibits STAT3. (+) -Ochromycinone is used in the researches of cancers and psoriasis[1][2].

Product Specifications

CAS Number

[28882-53-3]

Product Name Alternative

STA-21

UNSPSC

12352005

Target

Antibiotic; STAT

Type

Reference compound

Related Pathways

Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/plus-ochromycinone.html

Purity

98.20

Solubility

10 mM in DMSO

Smiles

O=C1C[C@@H](C)CC(C1=C2C3=O)=CC=C2C(C4=C3C=CC=C4O)=O

Molecular Formula

C19H14O4

Molecular Weight

306.31

References & Citations

[1]Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102 (13) :4700-5.|[2]Miyoshi K, et al. Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. J Invest Dermatol. 2011 Jan;131 (1) :108-17.