(+) -Ochromycinone
(+) -Ochromycinone is a natural antibiotic that potently inhibits STAT3. (+) -Ochromycinone is used in the researches of cancers and psoriasis[1][2].
Product Specifications
CAS Number
28882-53-3
Product Name Alternative
STA-21
UNSPSC
12352005
Target
Antibiotic; STAT
Type
Reference compound
Related Pathways
Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/plus-ochromycinone.html
Purity
98.20
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@H](C)CC(C1=C2C3=O)=CC=C2C(C4=C3C=CC=C4O)=O
Molecular Formula
C19H14O4
Molecular Weight
306.31
References & Citations
[1]Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102 (13) :4700-5.|[2]Miyoshi K, et al. Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. J Invest Dermatol. 2011 Jan;131 (1) :108-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
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