Spiraprilat

Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF) [1].

Product Specifications

CAS Number

[83602-05-5]

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/spiraprilat.html

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H]1CC2(SCCS2)CN1C([C@H](C)N[C@@H](CCC3=CC=CC=C3)C(O)=O)=O

Molecular Formula

C20H26N2O5S2

Molecular Weight

438.56

References & Citations

[1]Nakazawa M, et al. Effects of spiraprilat, an angiotensin-converting enzyme inhibitor, on anesthetized dogs in a new model of acute left ventricular failure. J Cardiovasc Pharmacol. 1993 Oct;22 (4) :585-93.