Nemorosone

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

Product Specifications

CAS Number

[351416-47-2]

UNSPSC

12352005

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nemorosone.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1)[C@@]23C([C@@](C(C(C/C=C(C)/C)=C2O)=O)(C[C@H](C/C=C(C)/C)C3(C)C)C/C=C(C)/C)=O

Molecular Formula

C33H42O4

Molecular Weight

502.68

References & Citations

[1]Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21 (5) :1827. Published 2020 Mar 6.|[2]Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8 (9) :e74555. Published 2013 Sep 5.