Rac-Vofopitant-d3
Rac-Vofopitant-d3 (rac-GR 205171-d3) is the deuterium labeled Vofopitant (HY-12142) [1]. Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively[2].
Product Specifications
Product Name Alternative
Rac-GR 205171-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Neurokinin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
[2H]C(OC1=CC=C(N2C(C(F)(F)F)=NN=N2)C=C1CNC3C(C4=CC=CC=C4)NCCC3)([2H])[2H]
Molecular Formula
C21H20D3F3N6O
Molecular Weight
435.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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