Kuraridine

Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC50=0.64 μM) [1].

Product Specifications

CAS Number

[34981-25-4]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/kuraridine.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=C(OC)C=C(O)C(C[C@H](C(C)=C)C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2O

Molecular Formula

C26H30O6

Molecular Weight

438.51

References & Citations

[1]Hye Joo Shin, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12 (17) :2313-6.|[2]Xinzhou Yang, et al. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root) . Mol Divers. 2011 May;15 (2) :361-72.