Kuraridine
Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC50=0.64 μM) [1].
Product Specifications
CAS Number
34981-25-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/kuraridine.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=C(OC)C=C(O)C(C[C@H](C(C)=C)C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2O
Molecular Formula
C26H30O6
Molecular Weight
438.51
References & Citations
[1]Hye Joo Shin, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12 (17) :2313-6.|[2]Xinzhou Yang, et al. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root) . Mol Divers. 2011 May;15 (2) :361-72.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PDE5
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