Dinactin
Product Specifications
UNSPSC Description
Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 μM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1].
Target Antigen
Antibiotic; Wnt; β-catenin
Type
Natural Products
Related Pathways
Anti-infection;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Infection
Assay Protocol
https://www.medchemexpress.com/dinactin.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3CC)=O)C)CC5)C)=O)C)([H])CC4
Molecular Weight
764.98
References & Citations
[1]Aehtesham Hussain, et al. Identification of dinactin, a macrolide antibiotic, as a natural product-based small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Cancer Chemother Pharmacol. 2019 Sep;84(3):551-559.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121333/Dinactin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121333/
Clinical Information
No Development Reported
CAS Number
20261-85-2
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