Dinactin

Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 μM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1].

Product Specifications

CAS Number

[20261-85-2]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Wnt; β-catenin

Type

Natural Products

Related Pathways

Anti-infection; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Neurological Disease; Infection

Assay Protocol

https://www.medchemexpress.com/dinactin.html

Solubility

10 mM in DMSO

Smiles

CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3CC)=O)C)CC5)C)=O)C)([H])CC4

Molecular Formula

C42H68O12

Molecular Weight

764.98

References & Citations

[1]Aehtesham Hussain, et al. Identification of dinactin, a macrolide antibiotic, as a natural product-based small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Cancer Chemother Pharmacol. 2019 Sep;84 (3) :551-559.