Kendomycin
Product Specifications
UNSPSC Description
Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent[1][2].
Target Antigen
Antibiotic; Bacterial; CGRP Receptor; Endothelin Receptor
Type
Reference compound
Related Pathways
Anti-infection;GPCR/G Protein;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/kendomycin.html
Purity
98.00
Solubility
DMSO : 1 mg/mL (ultrasonic;warming)
Smiles
OC(C1=O)=C([C@]([C@@H]([C@H]2O)C)([H])O[C@@](CC[C@@H]3C)([H])[C@@H]2C)C(C(O4)=C1C)=C[C@@]4([C@H](C[C@@H](C/C(C)=C/3)C)C)O
Molecular Weight
486.64
References & Citations
[1] Yasser A Elnakady, et al. Investigations to the Antibacterial Mechanism of Action of Kendomycin. PLoS One. 2016 Jan 21;11(1):e0146165.|[2]Yu Yuan, et al. Total synthesis of kendomycin: a macro-C-glycosidation approach. J Am Chem Soc. 2004 Nov 17;126(45):14720-1.|[3]Tetsuya Sengoku, et al. Total synthesis of the antibiotic kendomycin: a macrocyclization using the Tsuji-Trost etherification. Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4213-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121300/Kendomycin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121300/Kendomycin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
183202-73-5
Curated Selection
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