Delapril

Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].

Product Specifications

CAS Number

83435-66-9

Product Name Alternative

CV-3317

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/delapril.html

Solubility

10 mM in DMSO

Smiles

CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N(C2CC3=C(C=CC=C3)C2)CC(O)=O)=O)=O

Molecular Formula

C26H32N2O5

Molecular Weight

452.54

References & Citations

[1]Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43 (3) :242-9. |[2]Hernandez A, et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137 (1) :71-6. |[3]Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42 (1) :1-8. |[4]Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43 (3) :242-9. |[5]Hernandez A, et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137 (1) :71-6. |[6]Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42 (1) :1-8.