GW274150 (dihydrochloride)

GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM) . GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS) . GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation[1][2][3].

Product Specifications

CAS Number

[438542-17-7]

UNSPSC

12352211

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gw274150-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl

Molecular Formula

C8H19Cl2N3O2S

Molecular Weight

292.23

References & Citations

[1]Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145 (3) :301-12.|[2]Broom L, et al. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease.Free Radic Biol Med. 2011 Mar 1;50 (5) :633-40.|[3]Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141 (6) :979-87. Epub 2004 Feb