Balanol
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM) . Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS) . Balanol can be isolated from the fungus Verticillium balanoides[1][2].
Product Specifications
CAS Number
63590-19-2
Product Name Alternative
Ophiocordin; Azepinostatin
UNSPSC
12352005
Target
MARCKS; PKA; PKC
Type
Natural Products
Related Pathways
Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/balanol.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O
Molecular Formula
C28H26N2O10
Molecular Weight
550.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKA; PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCη
Frequently Asked Questions
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