Balanol

Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM) . Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS) . Balanol can be isolated from the fungus Verticillium balanoides[1][2].

Product Specifications

CAS Number

[63590-19-2]

Product Name Alternative

Ophiocordin; Azepinostatin

UNSPSC

12352005

Target

MARCKS; PKA; PKC

Type

Natural Products

Related Pathways

Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/balanol.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O

Molecular Formula

C28H26N2O10

Molecular Weight

550.51

References & Citations

[1]Gustafsson AB, et al. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug;56 (2) :377-82. |[2]Kulanthaivel P, et al. Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides. Journal of the American Chemical Society, 1993, 115 (14) : 6452-6453.