L-NIL (dihydrochloride)

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].

Product Specifications

CAS Number

[159190-45-1]

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-nil-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CCCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl

Molecular Formula

C8H19Cl2N3O2

Molecular Weight

260.16

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316 (4) :F624-F634.|[2]Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635.|[3]W M Moore, et al. L-N6- (1-iminoethyl) lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37 (23) :3886-8.