Ceefourin 2

Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].

Product Specifications

CAS Number

[348148-51-6]

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Others

Assay Protocol

https://www.medchemexpress.com/ceefourin-2.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=NN2C(C(F)(F)F)=CC(C3=CC=C(C=C3)C)=NC2=C1Cl

Molecular Formula

C15H9ClF3N3O2

Molecular Weight

355.70

References & Citations

[1]Cheung L, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4) . Biochem Pharmacol. 2014 Sep 1;91 (1) :97-108.