Eggmanone
Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade[1].
Product Specifications
CAS Number
[505068-32-6]
Product Name Alternative
EGM1
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eggmanone.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C(SCC(C2=CC=CS2)=O)=NC3=C1C4=C(CCCC4)S3)CC(C)=C
Molecular Formula
C20H20N2O2S3
Molecular Weight
416.58
References & Citations
[1]Williams CH, et al. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 2015;11 (1) :43-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Curated Selection
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