Anagyrine (hydrochloride)
Anagyrine ((-) -Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR[1][2][3].
Product Specifications
CAS Number
74195-83-8
Product Name Alternative
(-) -Anagyrine (hydrochloride) ; Monolupine (hydrochloride) ; Rhombinine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301-H360
Target
MAChR; nAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anagyrine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C([C@]3([H])C[C@]([C@]4([H])N(CCCC4)C3)([H])C2)=CC=C1.Cl
Molecular Formula
C15H21ClN2O
Molecular Weight
280.79
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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