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(rac) -AG-205

(rac) -AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac) -AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].

Product Specifications

CAS Number

442656-02-2

UNSPSC

12352005

Target

Akt; NF-κB

Type

Reference compound

Related Pathways

NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/rac-ag-205.html

Solubility

10 mM in DMSO

Smiles

CC1=CC2=C(C=C1)N(C3C2CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O

Molecular Formula

C22H23ClN6OS

Molecular Weight

454.98

References & Citations

[1]Cahill MA. Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins. Front Biosci (Landmark Ed) . 2022 Nov 30;27 (11) :317

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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