(S) -Bromoenol lactone

(S) -Bromoenol lactone ((S) -BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM[1].

Product Specifications

CAS Number

[478288-94-7]

Product Name Alternative

(S) -BEL; (S, E) -Bromoenol lactone

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-bromoenol-lactone.html

Concentration

3.15 mM * 1 mL in Methyl acetate

Purity

99.1

Solubility

10 mM in DMSO

Smiles

O=C1[C@H](C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br

Molecular Formula

C16H13BrO2

Molecular Weight

317.18

References & Citations

[1]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277 (36) :32807-14.