Butaprost (free acid)

Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].

Product Specifications

CAS Number

[215168-33-5]

UNSPSC

12352200

Hazard Statement

H225, H319, H336

Target

Prostaglandin Receptor; TGF-beta/Smad

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/butaprost-free-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCCCC[C@@H]1[C@@H](/C=C/C[C@@H](O)C2(CCC)CCC2)[C@H](O)CC1=O

Molecular Formula

C23H38O5

Molecular Weight

394.54

Precautions

H225, H319, H336

References & Citations

[1]Yanbin Liang, et al. Upregulation of orphan nuclear receptor Nur77 following PGF (2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP (2) receptor activated Nur77 gene transcription. Br J Pharmacol. 2004 Jun;142 (4) :737-48.|[2]Michael Schou Jensen, et al. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta Physiol (Oxf) . 2019 Sep;227 (1) :e13291. |[3]K Tani, et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett. 2001 Aug 6;11 (15) :2025-8.