WAY-207024 (dihydrochloride)

WAY-207024 dihydrochloride is an orally active gonadotropin releasing hormone receptor (GnRH-R) antagonist (human GnRH: IC50 of 12 nM, rat GnRH: IC50 of 71 nM) . WAY-207024 dihydrochloride inhibits rat LH release with an IC50 of 350 nM. WAY-207024 dihydrochloride lowers rat plasma leuteinizing hormone (LH) levels after oral administration[1].

Product Specifications

CAS Number

[872002-73-8]

UNSPSC

12352005

Target

GnRH Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/way-207024-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(C2=NC3=CC=CC(N4CCN(CC5=CC=C6N=CC=NC6=C5)CC4)=C3N2)C=C1)(C)C.[H]Cl.[H]Cl

Molecular Formula

C30H34Cl2N6

Molecular Weight

549.54

References & Citations

[1]Pelletier JC, et al. Discovery of 6- ({4-[2- (4-tert-butylphenyl) -1H-benzimidazol-4-yl]piperazin-1-yl}methyl) quinoxaline (WAY-207024) : an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R) . J Med Chem. 2009 Apr 9;52 (7) :2148-52.