S 16474
S 16474 is a cyclic peptide with antagonistic effects on NK1 and NK2 receptors. S 16474 can be used in the study of neurogenic inflammation[1].
Product Specifications
CAS Number
[149250-10-2]
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-16474.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N(CC1=CC=CC=C1)C)CC2=CC=CC=C2)NC([C@H](NC(C[C@@H]3NC([C@@]([H])(N4C3=O)C5CCC4CC5)=O)=O)CC6=CN(C7=C6C=CC=C7)C(CCC(O[Na])=O)=O)=O
Molecular Formula
C44H47N6NaO8
Molecular Weight
810.87
References & Citations
[1]Robineau P, et al. In vitro and in vivo pharmacology of S 16474, a novel dual tachykinin NK1 and NK2 receptor antagonist. Eur J Pharmacol. 1995 Dec 29;294 (2-3) :677-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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