BRD9185

BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].

Product Specifications

CAS Number

[2057420-29-6]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/brd9185.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@H]([C@H]([C@H]1C#N)C2=CC=C(C3=CC=C(C(C(F)(F)F)=C3)C(F)(F)F)C=C2)CO)NCCC

Molecular Formula

C23H21F6N3O2

Molecular Weight

485.42

References & Citations

[1]Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8 (4) :438-442.