GSK-3β inhibitor 8
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM) . GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].
Product Specifications
CAS Number
[1139875-74-3]
UNSPSC
12352005
Target
GSK-3; Wnt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-8.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC2=NC=CC(C3=CC=CS3)=N2)C=C1Cl)N4CCN(C)CC4
Molecular Formula
C20H20ClN5OS
Molecular Weight
413.92
References & Citations
[1]Wang W, et al. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2009 Feb 3;106 (5) :1427-32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
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