HX600
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].
Product Specifications
CAS Number
172705-89-4
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hx600.html
Purity
99.40
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(C2=NC3=CC=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1
Molecular Formula
C29H30N2O2
Molecular Weight
438.56
References & Citations
[1]Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11 (2) :164-71.|[2]Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233 (1) :121-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RXRα; RXRβ; RXRγ
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