TASP0376377

TASP0376377 is a potent and selective CRTH2 antagonist (IC50: 13 nM) . TASP0376377 has binding affinity for CRTH2 (IC50: 19 nM) [1].

Product Specifications

CAS Number

[1233246-60-0]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tasp0376377.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C=C1)C(C2=NC=C(C3=C2C=CC=C3)CC(O)=O)=O)C4=CC=C(C(Cl)=C4)Cl

Molecular Formula

C25H16Cl2N2O4

Molecular Weight

479.31

References & Citations

[1]Nishikawa-Shimono R, et al. Isoquinoline derivatives as potent CRTH2 antagonists: design, synthesis and SAR. Bioorg Med Chem. 2013 Dec 15;21 (24) :7674-85.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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