TASP0376377
TASP0376377 is a potent and selective CRTH2 antagonist (IC50: 13 nM) . TASP0376377 has binding affinity for CRTH2 (IC50: 19 nM) [1].
Product Specifications
CAS Number
[1233246-60-0]
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tasp0376377.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C=C1)C(C2=NC=C(C3=C2C=CC=C3)CC(O)=O)=O)C4=CC=C(C(Cl)=C4)Cl
Molecular Formula
C25H16Cl2N2O4
Molecular Weight
479.31
References & Citations
[1]Nishikawa-Shimono R, et al. Isoquinoline derivatives as potent CRTH2 antagonists: design, synthesis and SAR. Bioorg Med Chem. 2013 Dec 15;21 (24) :7674-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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