Heptelidic acid

Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].

Product Specifications

CAS Number

[57710-57-3]

Product Name Alternative

Koningic acid

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Antibiotic; Caspase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/heptelidic-acid.html

Purity

97.5

Solubility

10 mM in DMSO|DMSO : ≥ 30mg/mL

Smiles

O=C(C1=C[C@@]2([H])[C@]([C@@]3(OC3)CC[C@@H]2C(C)C)([H])C(OC1)=O)O

Molecular Formula

C15H20O5

Molecular Weight

280.32

Precautions

H302+H312+H332

References & Citations

[1]Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo) . 1980 May;33 (5) :468-73.|[2]Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19 (8) :787-91.|[3]Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26 (4) :648-659.e8.