Heptelidic acid
Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].
Product Specifications
CAS Number
[57710-57-3]
Product Name Alternative
Koningic acid
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Antibiotic; Caspase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/heptelidic-acid.html
Purity
97.5
Solubility
10 mM in DMSO|DMSO : ≥ 30mg/mL
Smiles
O=C(C1=C[C@@]2([H])[C@]([C@@]3(OC3)CC[C@@H]2C(C)C)([H])C(OC1)=O)O
Molecular Formula
C15H20O5
Molecular Weight
280.32
Precautions
H302+H312+H332
References & Citations
[1]Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo) . 1980 May;33 (5) :468-73.|[2]Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19 (8) :787-91.|[3]Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26 (4) :648-659.e8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Available Sizes
Curated Selection
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