Navafenterol (saccharinate)
Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for the research of chronic obstructive pulmonary disease (COPD) . Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile[1].
Product Specifications
CAS Number
1648550-37-1
Product Name Alternative
AZD-8871 (saccharinate) ; LAS191351 (saccharinate)
UNSPSC
12352005
Target
Adrenergic Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/navafenterol-saccharinate.html
Solubility
10 mM in DMSO
Smiles
O=C(C(O)(C1=CC=CS1)C2=CC=CS2)O[C@H]3CC[C@@H](CC3)N(C)CCCN4N=NC5=CC(CNC[C@H](O)C6=CC=C(C7=C6C=CC(N7)=O)O)=CC=C54.O=S8(C9=CC=CC=C9C(N8)=O)=O
Molecular Formula
C45H47N7O9S3
Molecular Weight
926.09
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MAChR3
Frequently Asked Questions
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