Navafenterol (saccharinate)

Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for the research of chronic obstructive pulmonary disease (COPD) . Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile[1].

Product Specifications

CAS Number

[1648550-37-1]

Product Name Alternative

AZD-8871 (saccharinate) ; LAS191351 (saccharinate)

UNSPSC

12352005

Target

Adrenergic Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/navafenterol-saccharinate.html

Solubility

10 mM in DMSO

Smiles

O=C(C(O)(C1=CC=CS1)C2=CC=CS2)O[C@H]3CC[C@@H](CC3)N(C)CCCN4N=NC5=CC(CNC[C@H](O)C6=CC=C(C7=C6C=CC(N7)=O)O)=CC=C54.O=S8(C9=CC=CC=C9C(N8)=O)=O

Molecular Formula

C45H47N7O9S3

Molecular Weight

926.09

References & Citations

[1]Mònica Aparici, et al. Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/ β 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile. J Pharmacol Exp Ther. 2019 Jul;370 (1) :127-136.