Yhhu-3792 (hydrochloride)
Product Specifications
UNSPSC Description
Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride has the potential for the research of impairment of learning and memory associated DG dysfunction[1].
Target Antigen
Notch
Type
Reference compound
Related Pathways
Neuronal Signaling;Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/yhhu-3792-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.NC1=C2C(OC3=CC=CC(OC)=C3)=CC=CC2=NC(NC4=CC=C(C(C)C)C=C4)=N1
Molecular Weight
436.93
References & Citations
[1]Lu H, et al. A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice. Stem Cells. 2018 Aug;36(8):1273-1285.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120782A/Yhhu-3792-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120782A/
Clinical Information
No Development Reported
CAS Number
2624336-93-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1428522-01 0.02 mg (E-Coli)
Recombinant Pongo abelii NSFL1 cofactor p47 (NSFL1C)
Ask
View Details 